KME Anti-aging

Assessment of the state of the body's functional systems.

• Assessment of the state of organs and tissues within functional systems
• Each functional system includes specific organs and tissues that determine how it works. For example, the digestive system consists of the intestine, liver, stomach, etc. The KME allows you to assess the condition and function of each of these comprising organs.
  • Tissue metabolism

  • Each organ's tissue consists of specialized cells and the external environment in which they live and function. This environment is called the extracellular matrix. The rate of metabolic processes in an organ is determined by the degree of functional activity of this organ's cells and the extracellular matrix.

    • Extracellular matrix.

    • The extracellular matrix (ECM) is a highly specific environment characteristic only of a particular organ's cells. The ECM provides the cells of the organ with nutrition through the blood capillaries that permeate the matrix. Tissue metabolites (products of the organ cells) are excreted through the ECM through the venous and lymphatic capillaries. The matrix also provides regulatory interactions between the cells of this organ. Regulatory signals controlling cell functioning are transmitted through the ECM. Disturbance of the matrix structure and function is at the root of all diseases and the body's aging.

    • State of the vascular system of the matrix.

    • Vessels in the matrix are represented by arterial, venous, and lymphatic capillaries. Through the arterial capillaries in the matrix, cells receive nutrition. Thanks to the work of the venous and lymphatic capillaries, cellular metabolites and toxins are removed from the matrix. The state of the vessels penetrating the matrix affects both the ECM's function and all cells' function.

    • The nutritional function of the extracellular matrix (cell nutrition).

    • Arterial capillaries in the matrix provide nutrients and oxygen for the vital functions of cells. Impaired arterial microcirculation leads to decreased nutrition supply to the tissue of an organ.

    • Drainage function of the ECM.

    • Lymphatic and venous capillaries provide the drainage function of the matrix (removal of metabolites and toxins). Through the arterial blood, not only cells’ nutrients can enter the matrix, but also exogenous (external) toxins. There are also waste products of cells that can contain endogenous (internal) toxins. Most of the toxins, endogenous and exogenous, accumulate and deposit in the matrix, creating an overall toxic load on a specific organ or the body as a whole. Disruption of the organ tissue's drainage system leads to toxins accumulation in it and the risk of development of diseases.

    • Regulatory and communicative function of the ECM.

    • Through the blood’s arterial capillaries, various regulatory molecules, such as hormones, enzymes, immunoglobulins, etc., enter the matrix. At the same time, tissue cells produce their regulatory molecules (cytokines, growth factors, etc.). The state of the matrix's normal structure (i.e., normal tissue morphology), the absence of toxins in the matrix ensure the optimal functional activity of regulatory molecules in the tissue.

    In the KME system, it is possible to assess the state of all matrix functions and subsequently correct them.
  • Intracellular metabolism

  • A particular function of an organ is sustained by the level of vital activity of its cells.

    • Assessment of the energy function of a cell.

    • The cell’s energy function is supplied by the cell's own "energy stations" called mitochondria. With age and ailments, the number of mitochondria inside each cell decreases significantly. Disruption of mitochondria can lead not only to the interruption of the overall function of a cell but also to the cell’s demise.

    • Assessment of the state of intracellular synthesis (synthetic function of the cell).

    • The cell synthesizes (produces) a large number of different substances to ensure organ function. The cell's synthetic function depends both on the cell's energy and on the correct sequence of its functioning. Any change in intracellular synthesis affects the function and structure of the organ itself, as well as the quality and quantity of the functional molecules it produces.

    • Assessment of the state of the excretory function of the cell.

    • A large amount of "broken" molecules accumulate inside the cell in the course of its work. These accumulations disrupt the normal cellular function and are intracellular toxins. The cells have a mechanism for getting rid of such a "broken waist". This process of intracellular drainage, purification is called autophagy. Controlling the state of autophagy is an essential criterion for maintaining the optimum state of the cell.

    • Assessment of the protective function of the cell.

    • The work of each cell is aimed at performing and maintaining the function of the whole organ. Nature has provided a mechanism for getting rid of non-functional cells and replacing them with new, functional ones. In a normally functioning organ, old and poorly performing cells are eliminated by the mechanisms of apoptosis. Apoptosis is a natural process of controlled cell death to provide space for young cells. Using the KME system, it is possible to assess the state of intracellular metabolism and conduct apoptosis correction.

• Assessment of the state of the nervous system

• With the KME system's help, it is possible to assess the autonomic nervous system's (ANS’s) function based on the balance of the sympathetic and parasympathetic nervous systems. The function of the central nervous system (CNS) can be assessed by the functional state of the nerves and various brain structures. The KME allows assessing the functional state of the primary brain structures

  • Own systems of neuronal regulation

  • Nerves of the internal organs and brain structures are interconnected through regulatory molecules (signals) in the form of neurotransmitters, neuropeptides, neuromodulators, and neurohormones. These molecules provide all of the body's many functions. The KME system helps in evaluating the activity of neurotransmitters, neuropeptides, neuromodulators, neurohormones in the mechanisms of functional correction.

• Assessment of hormonal balance

• The hormonal balance of the human endocrine system is determined by the functioning of the organs and glands of the endocrine system itself and by regulatory molecules from the brain structures. Therefore such regulation is often called neurohumoral. Premature aging of the human organism is directly related to a change in the balance of hormones in the body.

• Assessment of the body's immune status

• The human immune system is an integrative system that involves various organs and tissues. Its function manifests throughout the body. There are various criteria and markers in the KME system to assess the state of the immune system.

  • Inflammatory processes

  • An inflammatory process helps to maintain the protective function of the immune system. A chronic inflammatory process becomes pathological. The KME system makes it possible to assess the severity and depth of inflammatory processes and the body's immune response.

  • Sluggish inflammatory processes

  • Sluggish and chronic inflammatory processes reduce the functional activity of organs and tissues. These processes are characterized by a long-term decrease in the immune response and its polymorphism.

• Assessment of adaptation reserves of functional systems and organs.

• Adaptation reserves reflect the unique health resources of an individual. Adaptation reserves are the ability of the body's functional systems to respond actively and effectively to changes in external and internal environmental factors to restore normal body functions. It is the ability of the body to ensure its vital functions under all conditions. In the KME system, there are possibilities of individual assessment of the activity of adaptation reserves.